East Wheeling is the neighborhood that is located directly east of Downtown. While much of the neighborhood is made up of residential row houses and a few apartment buildings, it is balanced by numerous other institutions and businesses. As a National Historic District, there are numerous historic buildings throughout the neighborhood, especially of the Victorian era. East Wheeling also has a strong Catholic history and presence as the home of the Diocese of Wheeling-Charleston.
East Wheeling is a tight-knit community, but it is also within easy walking distance of Downtown and Center Wheeling. East Wheeling is home to several restaurants and markets that have come to be staples of Wheeling locals. For easy access to indoor or outdoor activity, the Nelson Jordan Center, the Wheeling Heritage Trail, a dog park, and playgrounds are all within the neighborhood. The eastern side of East Wheeling backs up to Wheeling Creek and there is easy access to Route 250.